Resident Evil is the film that began the nightmare for both fans and critics alike. Nightmare, of course, has a different connotation depending on who you're listening to. Resident Evil was written, directed and produced by Paul W.S. Anderson and starred Milla Jovovich, Michelle Rodriguez, Eric Mabius, James Purefoy, Martin Crewes and Colin Salmon.
Actress and genre crush Michelle Rodriguez has starred in Blue Crush , S.W.A.T. , Avatar , Battle: Los Angeles  and even made an appearance in Resident Evil: Retribution . She also appeared regularly in the TV series Lost.
Finally, Milla Jovovich needs no introduction. Apart from the Resident Evil franchise which she positively owns, highlights are many but include: The Fifth Element , He Got Game , The Messenger: The Story Of Joan Of Arc , Ultraviolet , A Perfect Getaway , The Fourth Kind  and many others.
So, yes, Resident Evil has some stripes on those genetically-altered arms.